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Yes, you can refuse to sign. But something has to be done; either the estate is administered and you get half of the house (or proceeds of sale of the house)[assuming only two siblings, no spouse] or else you disclaim your inheritance and your brother gets it all. If you won't disclaim, and you won't accept your half, then the estate administrator will have to turn your half over to the Division of State Lands, I suppose.

You may leave whatever you wish to your children. Your spouse, however, has the right to elected to take a share in your estate without regard to your will. If you have no assets or don't have many this won't mean much, but the spouse does have the right of election to take against your estate - you cannot disinherit a spouse.

You could disclaim (renounce) some of all of your inheritance. Unless the Will provides otherwise, the disclaimed property will go as if you had predeceased your relative. If it would then go to your children, they could also disclaim. If you have grandchildren who would then take, they could also disclaim. It is often possible to obtain court approval to disclaim on behalf of a minor. Keep in mind that the due date for a disclaimer is 9 months from date of death (or 9 months after reaching age 21, if later), and it takes some time to prepare the necessary papers (and to obtain court approval for disclaimers on behalf of any minors).